High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity

(Immunity 53, 759–774.e1–e9; October 13, 2020) In the originally published article, authors used chromatin immunoprecipitation sequencing (ChIP-seq) data for IRF4 to identify binding sites in cDC2 comparison with IRF8 cDC1. However, due an oversight during manuscript preparation, they did not upload ChIP-seq GEO repository. This has now been uploaded and available set GSE174011. The apologize any inconvenience. High Amount of Transcription Factor Engages AP1-IRF Composite Elements Enhancers Direct Type 1 Conventional Dendritic Cell IdentityKim et al.ImmunityAugust 2020In BriefDevelopment function conventional dendritic cell (cDC) subsets, cDC1 cDC2, depend on IRF4. Kim al. demonstrate that basis their distinct effects results from higher level IRF expressed cDC1, which is required selectively engage AICEs determine identity. Full-Text PDF Open Archive